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MAIN OUTCOME MEASURES : Diurnal intraocular pressure (IOP) at 8 AM, 10 AM, and 4 PM and safety variables (IOP was also measured at 8 PM at selected sites). RESULTS : Bimatoprost QD provided significantly lower mean IOP than timolol at every time of the.Baseline mean 8:00 AM IOP levels were similar (P.772 by week 12, reductions were observed in all 3 groups (P.001 for each). Adjusted (ANCOVA ) reductions in mean IOP at 8:00 AM were similar (P.128) as were those at 12 noon, 4:00 PM, and 8:00. The primary efficacy outcome measure was change between baseline and Week 12 in the 8:00 AM IOP (time of peak drug effect). RESULTS : In all, 410 of 411 randomized patients were included in intent-to-treat analyses (latanoprost, 136; bimatoprost, 136; travoprost, 138).
PURPOSE : To Internet Advance publication at m Feb 13, 2003. compare the intraocular pressure (IOP)-lowering effect and safety of latanoprost, bimatoprost, and travoprost in patients with open-angle glaucoma (OAG) or ocular hypertension (OH).At baseline and after 6 and 12 weeks of therapy, masked evaluators measured IOP in triplicate at 8:00 AM, 12 noon, 4:00 PM, and 8:00 PM, and masked investigators graded conjunctival hyperemia before the 8:00 AM IOP measurement.
CONCLUSIONS : Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients. Latanoprost exhibited greater ocular tolerability.CONCLUSIONS : Bimatoprost QD provides sustained IOP lowering superior to timolol or bimatoprost BID and achieves low target IOPs in significantly more patients.
A significantly higher percentage of patients receiving bimatoprost QD (58) than timolol (37) achieved IOPs at or below 17 mm Hg (10 AM, month 12; P.001). The most common adverse effect with bimatoprost was hyperemia (significantly higher with bimatoprost QD than timolol; P.001).DESIGN : Interventional study. METHODS : This 12-week, randomized, parallel-group study was conducted at 45 US sites. Previously treated patients with OAG or OH and an IOP or 23 mm Hg in one or both eyes after washout received either latanoprost 0.005, bimatoprost 0.03, or.