Bimatoprost week 2

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    Posted Jun 06, 2018 by Admin

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Bimatoprost week 2

Posted Apr 01, 2016 by Admin

RESULTS : 597 patients were randomised (bimatoprost PF, n302 and bimatoprost, n295). The 95 CI upper limit for worse eye IOP change from baseline was 1.5 mm Hg at each week 12 time point, meeting prespecified non-inferiority criteria.PubMed 11. Lindn C, Alm A. Effects on intraocular pressure and aqueous flow of various dose regimens of latanoprost in human eyes. Acta Ophthalmol Scand 1997;75:4125. PubMed 12. Ziai N, Dolan JW, Kacere RD, et al. BACKGROUND /AIM: To evaluate efficacy and safety of bimatoprost 0.03 preservative-free (PF) ophthalmic solution versus bimatoprost 0.03 (Lumigan) ophthalmic solution for glaucoma or ocular hypertension. METHODS : In this double-masked, parallel-group study, patients were randomised to bimatoprost PF or bimatoprost for 12 weeks.

1. Woodward DF, Krauss AH, Chen J, et al. The pharmacology of bimatoprost (Lumigan). Surv Ophthalmol 2001;45 (Suppl 4) :S33745. PubMed 2. Brubaker RF. Mechanism of action of bimatoprost (Lumigan). Surv Ophthalmol 2001;45 (Suppl 4) :S34751.Effects of PhXA41, a new prostaglandin F2 alpha analog, on aqueous humor dynamics in human eyes. Ophthalmology 1993;100:1297304. PubMed 5. Mishima HK, Kiuchi Y, Takamatsu M, et al. Circadian intraocular pressure management with latanoprost: diurnal and nocturnal intraocular pressure reduction and increased uveoscleral outflow.

PubMed 3. Brubaker RF, Schoff EO, Nau CB, et al. Effects of AGN 192024, a new ocular hypotensive agent, on aqueous dynamics. Am J Ophthalmol 2001;131:1924. PubMed 4. Toris CB, Camras CB, Yablonski ME.The primary analysis for non-inferiority was change from baseline in worse eye intraocular pressure (IOP) in the per-protocol population at week 12. For equivalence, it was average eye IOP in the intent-to-treat population at each time point at weeks 2, 6 and 12.

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Both treatments showed decreases in mean average eye IOP at all follow-up time points (p 0.001 were safe and well tolerated. CONCLUSIONS : Bimatoprost PF is non-inferior and equivalent to bimatoprost in its ability to reduce IOP-lowering with a safety profile similar to bimatoprost).Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems. Stat Med 2002;21:291730. PubMed 9. Nagasubramanian S, Sheth GP, Hitchings RA, et al. Intraocular pressure-reducing effect of PhXA41 in ocular hypertension.

Surv Ophthalmol 1997;41 (Suppl 2) :S13944. PubMed 6. Woodward DF, Krauss AH, Chen J, et al. Pharmacological characterization of a novel antiglaucoma agent, bimatoprost (AGN 192024). J Pharmacol Exp Ther 2003;305:77285.Ophthalmology 2001;108:102331. PubMed 15. Sherwood M, Brandt J. Six-month comparison of bimatoprost once-daily and twice-daily with timolol twice-daily in patients with elevated intraocular pressure. Surv Ophthalmol 2001;45 (Suppl 4) :S3618. PubMed 16.

The effects on aqueous dynamics of PhXA41, a new prostaglandin F2 alpha analogue, after topical application in normal and ocular hypertensive human eyes. Arch Ophthalmol 1993;111:13518. PubMed 13. Lindn C, Alm A.The 95 CI upper limit for the treatment difference for average IOP was 0.69 mm Hg and the lower limit was -0.50 mm Hg at all follow-up time points (hours 0, 2 and 8 at weeks 2, 6 and 12 meeting equivalence criteria.

Latanoprost twice daily is less effective than once daily: indication of receptor subsensitivity? Curr Eye Res 1998;17:56772. PubMed 14. Brandt JD, VanDenburgh AM, Chen K, et al. Comparison of once- or twice-daily bimatoprost with twice-daily timolol in patients with elevated IOP: a 3-month clinical trial.Am J Ophthalmol 2001;131:7989. PubMed.